By M.D. Esben Kirk
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Extra info for Acidosis. Clinical Aspects and Treatment with Isotonic Sodium Bicarbonate Solution
35 ' 30 The acidosis of hard muscular work is, as already mentioned, due to the fact that the supply of oxygen is insufficient in proportion to the muscular work. A disproportion between the supply of oxygen and the lactic acid combustion will, however, also occur under conditions in which the oxygen intake and the transfer of oxygen to the tissue is defective, that is to say, in cardiac decompensation and circulatory insufficiency. This anoxemic lactic acid acidosis has thus the same course of development as the physiological; but as a result of its pathogenesis it must be termed pathological and will be discussed in a special chapter.
By the use of a slightly hypertonic saline solution and oral ingestion of potassium permanganate. An essential feature of Rogers' treatment was the administration of very large amounts of fluid and frequent repetition of the treatment if necessitated by the condition of the patient, that is to say, on the whole a treatment along the lines indicated by Latta and his colleagues. c. (see Table 2). Of decisive importance for the attainment of favourable results was, according to Rogers, the early institution178' 180 of alkali treatment, since bicarbonate injections in the latest stages of uremia often caused symptomatic improvement only.
60 Acidosis Elias' 41 work is from the campaign in Russian Poland and Volynia in the years 1914-15. « The alkali treatment of these patients was intravenous, a 4 p. c. sodium carbonate solution being administered, and the therapy was especially tried on patients on whom repeated saline injections had been ineffective. During the injection of the concentrated alkaline solution consciousness gradually returned, by degrees the respiration grew calmer, and the patients began to talk. Almost regularly an improvement of 12-14 hours' duration set in, which in many apparently hopeless cases was the beginning of the patients' recovery.
Acidosis. Clinical Aspects and Treatment with Isotonic Sodium Bicarbonate Solution by M.D. Esben Kirk