By Frank J. Dixon
From the studies of past Volumes "Provides unrivalled worth in either educational and financial phrases and will be bought through difficult pressed librarians as a big precedence to be jealously defended." -JOURNAL OF clinical MICROBIOLOGY "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and institutions." -SCIENCE "A provocative and scholarly evaluate of research." -JOURNAL OF the yank scientific organization "Deserves an everlasting position in biomedical libraries as an relief in learn and in teaching." -JOURNAL OF IMMUNOLOGIC equipment
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Extra info for Advances in Immunology, Vol. 55
This work shows that SCF can regulate the secretory activity of mast cell, as well as influence their development. It is not yet clear to what extent SCF also can influence the functional activity of other lineages that express the SCFR. , 1992a). IX. Lymphohematopoiesis A. HEMATOPOIESIS In broad outline, hematopoiesis is characterized by the sustained self-renewal of a population of hematopoietic stem cells and by the regulated differentiation from this stem cell pool of various lineages with specialized function, such as red cells, megakaryocytes, granulocytes, monocytes, and mast cells.
Taken together, these findings indicate that the development and survival of mouse hematopoietic stem cells can occur in the absence of interactions between SCF and its receptor, but that SCF may augment the numbers and/or the anatomical distribution of such stem cells, and that SCF/SCFR interactions are required for normal hematopoiesis. The observation that SZISCF mutant mice exhibit abnormal hematopoietic responses to acute injury, such as irradiation, indicates that another major role of SCF may be to contribute to hematopoiesis during states of hematopoietic stress (Russell, 1979).
STEM CELL FACTOR 37 VIII. Biological Consequences of Interactions between the SCF Receptor and Its Ligand A. ADHESION The membrane-associated form of SCF can mediate the adhesion of cells that express the SCFR. This point was first established by Flanagan et aZ. (1991), who demonstrated that in vitro-derived mouse mast cells adhered to COS cells that had been transfected with the membrane-associated (wild type) but not the soluble (SZd) form of SCF. SubsequentIy, Kaneko et aZ. (1991) and Adachi et aZ.
Advances in Immunology, Vol. 55 by Frank J. Dixon